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The evidence is somewhat indirect on these points because it is very difficult to actually measure the level of neurotransmitter in a person's brain.
Another line of research has investigated linkages between stress, depression, and norepinephrine.However, research results also tell us that not all people experience mood changes in response to decreased norepinephrine levels.Some people who are depressed actually show hyperactivity within the neurons that produce norepinephrine.Neurons are constantly communicating with each other by way of exchanging neurotransmitters.This communication system is essential to all of the brain's functions.The neurotransmitters are then repackaged and reused the next time a message needs to be sent across the synapse.
Even though this seems like a complicated set of steps, this entire information transmission cycle occurs in the brain within in a matter of seconds.
A literal ton of research has been done on the causes of depression.
Below is a brief discussion of the multiple biological, psychological and social factors that have been identified as being related to the development of depression.
Neurochemistry The brain uses a number of chemicals as messengers to communicate with other parts of itself and with the nervous system.
These chemical messengers, called neurotransmitters, are released and received by the brain's many nerve cells, which are also called neurons.
Any problem that interrupts the smooth functioning of this chain of chemical events can negatively impact both the brain and nervous system.