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The cells were later commercialized, although never patented in their original form.
There have also been studies on He La cells, the effects of flavonoids and antioxidants with estradiol on cancer cell proliferation.He La cells were used to investigate the phytochemical compounds and the fundamental mechanism of the anticancer activity of the ethanolic extract of mango peel (EEMP).EEMP was found to contain various phenolic compounds and to activate death of human cervical malignant He La cells through apoptosis, which suggests that EEMP may help to prevent cervical cancer as well as other types of cancers.These were the first human cells grown in a lab that were naturally "immortal", meaning that they do not die after a set number of cell divisions (i.e. These cells could be used for conducting a multitude of medical experiments—if the cells died, they could simply be discarded and the experiment attempted again on fresh cells from the culture.This represented an enormous boon to medical and biological research.Jay Shendure led a He La sequencing project at the University of Washington which produced a paper that had been accepted for publication in March 2013—but that was also put on hold while the Lacks family's privacy concerns were being addressed.
A data-access committee will review requests from researchers for access to the genome sequence under the criteria that the study is for medical research and the users will abide by terms in the He La Genome Data Use Agreement, which includes that all NIH-funded researchers will deposit the data into a single database for future sharing.
In 2011, He La cells were used in tests of novel heptamethine dyes IR-808 and other analogs which are currently being explored for their unique uses in medical diagnostics, the development of theranostics, the individualized treatment of cancer patients with the aid of PDT, co-administration with other drugs, and irradiation.
which prevents the incremental shortening of telomeres that is implicated in aging and eventual cell death.
Researchers have also noted how stable these aberrant karyotypes can be: Human papillomaviruses (HPVs) are frequently integrated into the cellular DNA in cervical cancers.
We mapped by FISH five HPV18 integration sites: three on normal chromosomes 8 at 8q24 and two on derivative chromosomes, der(5)t(5;22;8)(q11;q11q13;q24) and der(22)t(8;22)(q24;q13), which have chromosome 8q24 material. Dual-color FISH with a c-MYC probe mapping to 8q24 revealed colocalization with HPV18 at all integration sites, indicating that dispersion and amplification of the c-MYC gene sequences occurred after and was most likely triggered by the viral insertion at a single integration site.
In this way, the cells circumvent the Hayflick limit, which is the limited number of cell divisions that most normal cells can undergo before becoming senescent.